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This study is a great example of the anabolic effect ostarine has on the body: Ostarine treatment resulted in a dose dependent increase in total LBM, with an increase of 1.5% at 1.5 times the placebo. The increase in total LBM is comparable to the increase that occurs with increased caloric intake. When ostarine was administered in isolation and in higher doses than the previous study, we observed that there were no significant differences between the three groups in the percentage change in body mass change. However, the average amount that ostarine treated subjects ingested was greater than the amount that was in the placebo group as expected. This means that the anabolic effect of ostarine was only observed when both ostarine and the placebo were given in a single dose. When ostarine was administered in combination with a calorie supplement, ostarine did not induce a significant increase in the percentage change in body mass, and there was no significant difference between the three groups with respect to the percentage increase. However, if ostarine was administered alone in a larger dose, there was a significant increase of 3.1% in the percentage of body mass change between the placebo and ostarine treated subjects. This study supports research by others that indicate that supplementing a high-energy, high-carbohydrate meal with ostarine can result in an increased amount of muscular mass (Kruger et al, 2009). Conclusion The studies presented in this review show that ostarine can be effective in improving physical performance and increasing strength and endurance in bodybuilders. Although many people want to use ostarine to improve their energy and prevent muscle loss, research and results suggest that supplementing with ostarine can also improve athletic performance. For athletic performance enhancement, ostarine is most effective when administered to a relatively low dose (<1 mg/kg); when used in combination with calorie supplements the anabolic effect is greater. This may explain why this supplement does not seem to have an additional positive effect on endurance performance. Further studies are required to determine if a therapeutic dose of ostarine is an effective route of treatment. References Bartholomew R. B., Lechner F. M. D. & Spangler C. M. (2010). Changes in skeletal muscle mass and composition following prolonged consumption of ostarine and its major metabolite, ostarine propionate. The Journal of Clinical Endocrinology & Metabolism, 98(3), 795-800. doi: 10.1210/jc.2009-2773. Retrieved from: http://onlinelibrary.wiley.com/doi Related Article: